Peningkatan Kadar Glukosa Darah terhadap Infeksi Tuberkulosis  Penderita Diabetes Mellitus Puskesmas Ngasem, Kediri

Authors

  • Ravega Surya Adam Damono Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
  • Enny Willianti Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
  • Emillia Devi Dwi Ratnasari Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya

DOI:

https://doi.org/10.30742/s8zds570

Keywords:

Blood Sugar Level, Diabetes Mellitus, Tuberculosis

Abstract

Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and remains a major global public health problem. In Indonesia, 397,377 TB cases were detected in 2021, while the treatment success rate has not yet reached the expected target. Objective: This study aimed to analyze the association between blood glucose levels and TB infection among patients with diabetes mellitus at Ngasem Primary Health Center, Kediri Regency. Methods: This observational study employed an analytical approach. The study population consisted of 131 patients with diabetes mellitus, of whom 99 respondents were selected using purposive sampling. The independent variable was blood glucose level, while the dependent variable was TB infection. Results: Data were analyzed using Fisher’s Exact Test. The findings showed that most respondents had uncontrolled blood glucose levels (53.5%), and the majority were not infected with TB (84.8%). Statistical analysis revealed a significant association between blood glucose levels and TB infection among patients with diabetes mellitus (p = 0.001). Conclusion: These findings indicate the importance of maintaining optimal blood glucose control to reduce the risk of TB infection among patients with diabetes mellitus.

References

Abbas, U., et al. (2022). Tuberculosis and diabetes mellitus: Immune dysregulation and disease

progression. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 29, 100343. https://doi.org/10.1016/j.jctube.2022.100343

American Diabetes Association. (2021). Standards of medical care in diabetes—2021. Diabetes Care, 44(Suppl. 1), S11–S16. https://doi.org/10.2337/diacare.29.02.06.dc05-1989

Decroli, E. (2019). Diabetes melitus tipe 2. Universitas Andalas Press.

Foe-Essomba, J. R., Kenmoe, S., Tchatchouang, S., et al. (2021). Diabetes mellitus and

tuberculosis: A systematic review and meta-analysis. PLOS ONE, 16(12), e0261246. https://doi.org/10.1371/journal.pone.0261246

Flynn, J. L., & Chan, J. (2001). Immunology of tuberculosis. Annual Review of Immunology, 19, 93–129. https://doi.org/10.1146/annurev.immunol.19.1.93

Harahap, F. Z. (2021). Hubungan diabetes melitus dengan kejadian tuberkulosis: Studi case control di RSUD Kotapinang. Universitas Islam Negeri Sumatera Utara.

Kementerian Kesehatan Republik Indonesia. (2023). Laporan program penanggulangan tuberkulosis tahun 2022. Kemenkes RI.

Krishna, S., & Jacob, J. J. (2021). Diabetes mellitus and tuberculosis. In Endotext. NCBI

Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK570126/

Limatahu, S. R., Iskandar, D., & Natsir, B. (2023). Type 2 diabetes mellitus and tuberculosis risk: Immune pathway disruption. International Journal of Medical Science and Health Research.

Martinez, N., & Kornfeld, H. (2014). Diabetes and immunity to tuberculosis. European Journal of Immunology, 44(3), 617–626. https://doi.org/10.1002/eji.201344301

Mihardja, L., Lolong, D. B., & Ghani, L. (2015). Prevalensi diabetes melitus pada tuberkulosis dan masalah terapi. Indonesian Journal of Health Ecology, 14(4), 350–358. 10.22435/jek.v14i4.4714.350-358

Niazi, A. K., & Kalra, S. (2012). Diabetes and tuberculosis: A review of the role of optimal glycemic control. Journal of Diabetes & Metabolic Disorders, 11(28). https://doi.org/10.1186/2251-6581-11-28

Notoatmodjo, S. (2012). Metode penelitian kesehatan. Rineka Cipta.

Peng, Y.-F. (2024). Pulmonary tuberculosis and diabetes mellitus: Epidemiology and immune mechanisms. Medical International Journal, 4(1), 1–12. https://doi.org/10.3892/mi.2023.128

PERKENI. (2021). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. PB PERKENI. https://pbperkeni.or.id/unduhan

Presiden Republik Indonesia. (2021). Peraturan Presiden Republik Indonesia Nomor 67 Tahun 2021 tentang penanggulangan tuberkulosis.

Restrepo, B. I. (2016). Diabetes and tuberculosis. Microbiology Spectrum, 4(6). https://doi.org/10.1128/microbiolspec.TNMI7-0023-2016

Rochmah, W. (2014). Diabetes melitus. In S. Setiati et al. (Eds.), Ilmu penyakit dalam (6th ed.). FKUI.

Ssekamatte, P., et al. (2023). Immune dysfunction in diabetes and susceptibility to tuberculosis. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1122255

Tandra, H. (2018). Segala sesuatu yang harus Anda ketahui tentang diabetes. Gramedia.

Wijaya, I. (2015). Tuberkulosis paru pada penderita diabetes melitus. Cermin Dunia Kedokteran, 42(6), 412–417.

Wijayanto, A., Burhan, E., & Nawas, A. (2013). Faktor terjadinya tuberkulosis paru pada pasien diabetes mellitus tipe 2. Jurnal Respirasi, 35(1), 1–11.

Wilkinson, R. J. (2020). Tuberculosis and type 2 diabetes mellitus: Inflammatory interactions. Clinical Infectious Diseases, 72(1), 79–81. https://doi.org/10.1093/cid/ciaa747

World Health Organization. (2023). Global tuberculosis report 2023. https://www.who.int/publications/i/item/9789240083851

Wulandari, A. A., & Adi, M. S. (2015). Faktor risiko tuberkulosis paru. Jurnal Kesehatan Lingkungan Indonesia, 14(1). 10.14710/jkli.14.1.7-13

Downloads

Published

2026-06-30

Issue

Section

Original Research Article