Pengaruh Ekstrak Etanol Bawang Putih (Allium sativum) Dan Buah Pare (Momordica Charantia) Terhadap Kadar Gula Darah PadaTikus Putih Yang Hiperglikemik
DOI:
https://doi.org/10.30742/9qrq6v46Keywords:
Antidiabetic, Bitter melon, Garlic extract, HyperglycemiaAbstract
Background: Chronic metabolic disease, indicated by increased blood sugar levels due to problems in insulin production or function, one of which is type 2 diabetes mellitus. The use of natural ingredients such as garlic and bitter melon is another solution in treatment because of the presence of active compounds that have antidiabetic properties. Objective: To examine the impact of administering garlic and bitter melon ethanol extract on blood glucose levels in white rats (Rattus norvegicus) made hyperglycemic. Method: Experimental study with 7 treatment groups, which include negative control (K−), positive control (K+), glibenclamide drug (P0), Garlic ethanol extract doses of 100 mg/kgBW (P1) and 150 mg/kgBW (P2), and Bitter melon extract doses of 100 mg/kgBW (P3) and 150 mg/kgBW (P4). Blood glucose levels were measured after treatment for 14 days. Results: The highest average glucose levels were found in K+ (448.2 mg/dL) and the lowest in P4 (103.4 mg/dL). The Kruskal-Wallis test showed a significant difference between groups (p<0.05). Conclusion: Garlic and Bitter Melon Extracts were effective in lowering blood glucose levels, especially at a dose of 150 mg/kgBW of bitter melon fruit which showed the most significant decrease.
References
Auliah, S., & Asri, N. (2019). Aktivitas antioksidan buah pare. Jurnal Penelitian Herbal Indonesia, 7(2), 89–94.
Bilous, R., & Donelly, R. (2015). Buku Pegangan Diabetes (Edisi ke-4).
Cyntithia, L. G., Windarti, I., & Soleha, T. U. (2024). Pengaruh ekstrak bawang putih terhadap histopatologi pankreas. Jurnal Biomedik Indonesia, 8(1), 55–62.
Decroli, E. (2019). Diabetes Melitus. Pusat Penerbitan Bagian Ilmu Penyakit Dalam FK Universitas Andalas.
Desai, S., & Tatke, P. (2016). Charantin and its role in diabetes. Pharmacognosy Reviews, 10(20), 118–122.
El-Saber Batiha, G., et al. (2020). Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients, 12(3), 872. https://doi.org/10.3390/nu12030872
Ezekiel, O. (2021). Lipid peroxidation and polyherbal therapy. Accenting Lipid Peroxidation. https://doi.org/10.5772/intechopen.97625
Fadly, A., et al. (2022). Pengaruh ekstrak bawang putih terhadap kadar glukosa darah. Jurnal Medikah Utama, 5(1), 23–30.
Fitri, A., Sari, D. P., & Lestari, M. (2020). Efek samping terapi oral antidiabetes pada pasien DM tipe 2. Jurnal Farmasi Klinik Indonesia, 9(1), 45–52.
Hadiatun, N. (2024). Efektivitas ekstrak bawang putih dibandingkan glibenklamid dalam menurunkan glukosa darah. Jurnal Sains Natural, 6(2), 101–108.
Hakim, A. (2022). Pengaruh ekstrak etanol buah pare terhadap penurunan kadar glukosa darah. Jurnal Sains Biomedik, 6(3), 112–117.
Hasibuan, D. C., & Manurung, D. M. (2020). Efektivitas jus pare terhadap penurunan kadar gula darah pada penderita diabetes mellitus tipe II. Jurnal Kesehatan Ilmiah Indonesia, 5(2), 68. https://doi.org/10.51933/health.v5i2.318
Hazni, S., Ramadhani, R., & Yusuf, M. (2021). Hubungan kadar glukosa darah dengan komplikasi diabetes melitus. Jurnal Kesehatan, 9(2), 112–118.
Joseph, B. (2013). Antidiabetic potential of Momordica charantia. International Journal of Diabetes Research, 2(3), 45–50.
Kusuma, Y., et al. (2020). Aktivasi AMPK oleh charantin. Jurnal Fitofarmaka Indonesia, 7(1), 33–40.
Li, L., Wang, C., & Zhang, Y. (2022). Allicin modulates insulin resistance via PI3K/Akt pathway. Journal of Ethnopharmacology, 284, 114732. https://doi.org/10.1016/j.jep.2021.114732
Maruanaya, C. A. (2019). Efek ekstrak bawang putih dan buah pare terhadap kadar glukosa darah. Jurnal Kedokteran Eksperimental, 4(1), 55–60.
Noorratri, E. D. (2019). Peningkatan kualitas hidup pasien diabetes melitus dengan terapi fisik. Jurnal Ilmu Keperawatan Komunitas. https://doi.org/10.32584/jikk.v2i1.301
Nurvita, S. (2022). Perbandingan kasus baru dan lama diabetes mellitus tipe II di Puskesmas Bangetayu tahun 2016–2021. Jurnal Kesehatan Ilmiah Indonesia, 7(1). https://doi.org/10.51933/health.v7i1.761
PERKENI. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. PB Perkeni.
Saber, H., et al. (2020). Garlic extract and oxidative stress. Journal of Functional Foods, 70, 103985. https://doi.org/10.1016/j.jff.2020.103985
Saputri, R. D. (2020). Komplikasi sistemik pada pasien DM tipe 2. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 230–236. https://doi.org/10.35816/jiskh.v11i1.254
Sitomorang, R., et al. (2023). Morfologi dan kandungan aktif buah pare. Jurnal Hortikultura Tropika, 9(2), 77–85.
Sotoudeh, M., Fathi, S., & Shabani, M. (2022). S-allyl cysteine as antidiabetic agent. Phytomedicine, 38, 101177. https://doi.org/10.1016/j.phymed.2020.101177
Sunita, K., & Prasad, M. N. V. (2020). Hyperglycemia-induced oxidative stress. Oxidative Medicine and Cellular Longevity, 2020, 9829176. https://doi.org/10.1155/2020/9829176
Tamornpark, R., et al. (2022). Quality of life among diabetes patients. Health and Quality of Life Outcomes, 20(1), 81. https://doi.org/10.1186/s12955-022-01986-y
Yuda, K., & Maesaroh, Y. (2020). Aktivitas buah pare sebagai herbal anti hiperglikemia. Jurnal Kesehatan Herbal Indonesia, 12, 45–50.
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